A novel biomaterial for the treatment of periodontal disease defects ? Peridocure

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Summary: Slovenian researchers developed a simple procedure for modification of bacterial cellulose with micro structured gelatine coating. The invention can be used by periodontologists during treatment of periodontal defects in patients with progressive periodontitis. The research institution is searching partners active in the fields of dental, medical and pharmaceutical industry and is open for research, technical, commercial, license and joint venture agreements. Description Description: 

Researchers from Slovenian research institution founded in 1975 develop simple procedure for modification of bacterial cellulose with micro structured gelatine coating which resulted in a novel barrier membrane for guided tissue regeneration. The innovation is revolutionary answer for patients with long term treatment of periodontal defect.

Periodontitis is an inflammation of the gums and supporting structures of the teeth. It is one of the most common human diseases affecting 8% of the population between the age of 20 and 64 years. A novel biomaterial stimulates the regeneration of destroyed tissues around the tooth (bone, gingiva)

The novel composite membrane consists of a non-porous and a porous layer. The non-porous layer is made of biopolymer bacterial cellulose and serves as a biocompatible mechanical barrier to prevent epithelial migration. The porous layer made of gelatine acts as a scaffold and favours repopulation by cells from the bone cells, and most likely the periodontal ligament cells. Bilayer composite, composed of highly integrated, non-porous bacterial cellulose and highly porous gelatine is applicable for guided tissue regeneration. In this application, the non-porous part restrict proliferation on one cell type, while the porous part allows proliferation of another cells type. Additionally, the porous part is made of collagen derivative- gelatine, which is natural environment for most of human cells. Many clinical studies have demonstrated that guided tissue regeneration (GTR) is a successful treatment modality of periodontal reconstructive surgery and involves the use of a barrier membrane to impede the ingrowth of soft tissue into defect sites and promote periodontal tissue or bone regeneration.

This revolutionary invention will be used by periodontologist during treatment of periodontal defects in patients with progressive periodontitis, where bone loss is present.

The research institution is looking for a partner active in the fields of dental, pharmaceutical and medical industry to sign licence, joint venture and/or commercial agreement. Researchers seek out companies capable to further develop the technology towards a marketable product. With the functional prototype as a starting point the university is ready to support technical development by a research and/or technical cooperation agreement.

Advantages & innovations Cooperation plus value: - A novel biomaterial stimulates the regeneration of destroyed tissues around the tooth (bone, gingiva). - Novel barrier membrane for guided tissue regeneration is used to stimulate bone growth in the treatment of periodontal disease: prevent epithelial migration, maintain space, suport new connective tissue attachment.- The novel composite membrane consists of a non-porous and a porous layer. The non-porous layer is made of biopolymer bacterial cellulose and serves a biocompatible mechanical barrier to prevent epithelial migration.- The membrane can also be used for skin tissue regeneration. Stage of development Cooperation stage dev stage: Prototype available for demonstration Partner sought Cooperation area: The research institution is looking for a partner active in the fields of dental, pharmaceutical and medical industry to sign licence, joint venture and/or commercial agreement. Researchers seek out companies capable to further develop the technology towards a marketable product. With the functional prototype as a starting point the university is ready to support technical development by a technical cooperation agreement.
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