Poly(N?isopropylacrylamide)/mesoporous silica thermosensitive composite hydrogels for drug loading and release

» Autor: Zhaofu Zhang, Shuo Wang, Geoffrey I. N. Waterhouse, Qihai Zhang, Lifang Li

» Referencia: doi:10.1002/app.48391

» Fecha Publicaciˇn: 12/08/2019

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Schematic diagram of crosslinking mechanism of PNIPA/MSN composite hydrogel.Temperature?sensitive hydrogels are attracting increasing attention for controlled drug delivery. However, achieving high drug loadings and sustained drug release remains challenging. Herein, we describe the successful synthesis of a series of novel temperature?sensitive poly(N?isopropylacrylamide) (PNIPA)/mesoporous silica nanoparticles (MSN) hydrogels by physical crosslinking of NIPA with MSN. The external and internal structures, temperature sensitivity, drug?loading capacity, and blood compatibility of the PNIPA/MSN composite hydrogels are studied. Results show that MSN addition improved the network structure and adjusted the size of the hole, MSN could also act as drug carrier, thereby enhancing the drug loading capacity. The composite hydrogels underwent a phase transition at 33.7 ?C (at the lower critical solution temperature). The hemolysis rate of the composite hydrogels was less than 1%, thus they can be classified as a nonhemolytic materials with good biocompatibility. The composite hydrogels reported here thus have great potential in drug transport and temperature?activated drug release. ? 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48391.
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